Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity
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چکیده
منابع مشابه
Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity.
This paper evaluates CHCl3 and CH3OH extracts of the stem bark, branches and leaves of Drimys brasiliensis and drimane sesquiterpenes isolated from the stem bark against strains of Leishmania amazonensis and Leishmania braziliensis promastigotes and Plasmodium falciparum trophozoites. All of the extracts and compounds were tested in cell lines in comparison with reference standards and cell via...
متن کاملAnti-lipid Potential of Drimys brasiliensis
BACKGROUND The traditional use of Drimys brasiliensis Miers (Winteraceae) in the south of Brazil to reduce cholesterol has not been described in scientific literature. OBJECTIVE To verify the hypocholesterolemic effects of D. brasiliensis using rats as animal model. MATERIALS AND METHODS The bark of D. brasiliensis was extracted with water with further lyophilization and was subjected to ph...
متن کاملAntifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation.
PURPOSE This study describes the antifungal effect of extracts and compounds isolated from Drimys brasiliensis acting against dermatophytes. METHODS The activities were evaluated by using the microbroth dilution method. RESULTS Bioassay-guided fractionation of the most active extract from the bark (CHCl3) led to the isolation of the sesquiterpene drimanes polygodial, 1-beta-(p-methoxycinnam...
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The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6-(1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chro...
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Leishmaniasis and malaria are serious public health problems in tropical and sub-tropical regions worldwide. Development of drug-resistant strains has disrupted efforts to control the spread of these diseases in the world. The conventional antiparasitic chemotherapy still suffers from side effects and drug resistance. Therefore, the development of novel antimalarial and leishmanicidal drugs rem...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2013
ISSN: 0074-0276
DOI: 10.1590/0074-0276108022013002